We found this DCWL aloe vera juice to be nongenotoxic in histidine reversion and DNA repair assays. They also thank Dr. Nobuko Wakamatsu for her suggestions and helpful reading of the paper. The difference in plasma albumin was not felt to be a toxic effect since we found no differences in total protein, globulin, or serum protein in females and because albumin in males fed with the test extract was not different ( lnder Sehgal, 1 ' 2 . Review articles are excluded from this waiver policy. Hematology of whole blood from B6C3F1 mice administered aloe juice by gavage. $20.03 $ 20. :��Q�EMDM��e�ƩtzuRڼD���JЫw�g�����ĸy���X���T���Bu��}���}ϔ�F?rT�KzU��C�L~+M��Q��S}���ɉ�j��9.��Խ�� ConsumerLab said it tested a dozen aloe products, including pills and juices, and just half the items appeared to meet the claims on their labels. However, independent studies also show that absorption of Vitamin C increases by 2000% when taken with Lily of the Desert brand aloe vera. 99 ($0.23/Fl Oz) Save more with Subscribe & Save. Aloe vera can promote healthier skin. 1I.SU ~c/1111>/ •if \lflen1111ry M&lici11c, ,\kip Rrrt111a11 . At the study’s conclusion, weights of organs were not significantly different from control in either sex (Table 5), and gross necropsy was otherwise unremarkable. To date, no evaluation of the de-colorized whole leaf Aloe vera juice has been reported. NMR analysis of the resulting extract established (1) the presence of Aloe vera (by confirming the presence of aloe vera polysaccharide, malic acid, and glucose), (2) the presence of whole leaf markers (isocitrate and isocitrate-lactone), and (3) the absence of adulterants/stabilizers in the extract. However, attractive candidates are the anthraquinones associated with the latex in whole leaf juice but largely absent from activated charcoal-treated aloe. This particular product can be considered as being well characterized with regard to high-molecular-weight polysaccharide content [24] and immunomodulating activity [25, 26]. Other aloe vera components, such as polysaccharides that serve as growth substrates for Eubacterium [37], could alter intestinal flora in favor of glycosidase-capable bacteria. ��q���el�9QZ��T5�ɗ�W֭�� v��j�� ���6kYܢBvUve�k��F�Mc�Qv�5�������T�B���LX�޶�؋�B�S����+ �sL���"9��=���/8�=;[da+�{�U"��C���z�o�������Sh�ߙ����V���\-PM]YTe�{Պ3fő�����]E� J�RG�XE�o��$0������ The International Aloe Science Council is a non-profit trade organization for the Aloe Vera industry world-wide. Certain medications can interact badly with the active ingredients in aloe vera juice, particularly those with enzymes CYP3A4 and CYP2D6. Both the bitterness and green color are caused by the aloins. Lily of the Desert Aloe Vera Juice, Whole Leaf, 32 Ounces (Pack of 2) 4.6 out of 5 stars 917. Sections of liver from aloe-gavaged and control mice were microscopically examined. These data indicate that the rats in our study consumed an amount of aloe juice equivalent to the 1.0% aloe drinking water in the NTP study by malic acid equivalency. G. Gillis is employed by L.O.D. Hello Select your address Best Sellers Prime Video Today's Deals Books New Releases Help Home & Garden Gift Ideas Electronics Gift Cards & Top Up PC Vouchers Free Delivery Sell Shopper Toolkit Prime Video Today's Deals Books New Releases Help Home & Garden Gift Ideas Electronics Gift Cards & Top Up PC Vouchers Free Delivery Sell Aloe vera naturally contains 200 biologically-active components including polysaccharides, vitamins, enzymes and minerals that work harmoniously together to support overall health. Toxicology of various aloe products has been examined in vivo, and these studies collectively suggest that the potential for toxicity depends on the plant sections used in juice production.  mM, or Hematology and clinical chemistry values were generally not significantly different compared to controls although in some instances, a measured value for one parameter was different from the control at 2-Aminoanthracene (2.60 μM final concentration) was used as a positive control for mutagenesis requiring metabolism. For the DNA damage assay in E. coli, the DCWL juice was tested at levels of 21x, 14x, 7x, 3.5x, 1.75x, 0.88x, 0.44x, 0.22x, 0.11x, and 0.055x. Nair,2 and Konstantine Kousoulas. Recommended Daily Dose: 4 oz. Large intestine mucosal/goblet cell hyperplasias were also observed in mice exposed for two years; however, these mice did not show increased neoplasms and had similar survival and body weights as control groups. Toxicologic Assessment of a Commercial Decolorized Whole Leaf Aloe Vera Juice, Lily of the Desert Filtered Whole Leaf Juice with Aloesorb InderSehgal,1,2 WallaceD.Winters,3 MichaelScott,3 AndrewDavid,4 GlennGillis,5 ThayaStoufflet,4 AnandNair,2 andKonstantineKousoulas4 1LSUSchoolofVeterinaryMedicine,SkipBertmanDrive,BatonRouge,LA70803,USA Our aloe vera juice is made from certified organic aloe vera using only the inner gel filet to ensure the purest unadulterated aloe for maximum efficacy. External Benefits. The harvested leaves were washed, disinfected, and macerated to yield an intermediate raw material representative of a nondecolorized whole leaf extract as was used in the aforementioned NTP study. The small intestine was opened and grossly examined and preserved if lesions were observed. DCWL aloe vera juice extract when tested at up to a 21x concentration was not significantly mutagenic to test Salmonella spp. Make sure you only drink aloe vera juice that has been decolorized (purified) to reduce aloin levels. Charcoal treatment is necessary since the latex, which exists as a separate liquid between the outer rind and inner fillet gel, contains bitter phenolic molecules including anthraquinone C- and O-glycosides, anthrones, and some free anthraquinones [11]. All animal procedures followed the National Research Council’s “GUIDE FOR THE CARE AND USE OF LABORATORY ANIMALS” and were first reviewed and approved by the LSU IACUC. Organ weights were compared using an unpaired t-test with significance set a Necropsy evaluations, hematology, and clinical chemistries were generally similar to the control groups. The preservative does not affect the potency of the aloe vera. and supplied juice characterization data. In agreement with the results of others who have tested aloe vera from the inner gel fillet [18], we found no evidence to support genotoxic effects in bacterial assays. Aloe vera is a common ingredient in cosmetics, skin care products, and increasingly, beverages and food products [1]. Our data obtained using a DCWL aloe vera juice contrast with these previous results. During a subchronic period (13 weeks), mice administered aloe were similar to controls in most parameters with the exception of increased incidences of mucosal hyperplasia with goblet cell hyperplasia in the cecum and large intestine. Body weight, organ weights and all hematologic and clinical chemistry parameters were analyzed within each sex by Student’s t-test, with significance as Both body weight gains and feed consumption of rats fed the test extract were equivalent to the same parameters in the control males and females (Figures 2 and 3). Studies employing innately hypercholesterol rat models have shown a greater cholesterol-reducing effect of aloe [32]. Toxicologic Assessment of a Commercial Decolorized Whole Leaf Aloe Vera Juice, Lily of the Desert Filtered Whole Leaf Juice with Aloesorb, LSU School of Veterinary Medicine, Skip Bertman Drive, Baton Rouge, LA 70803, USA, Comparative Biomedical Sciences Department, LSU School of Veterinary Medicine, Skip Bertman Drive, Baton Rouge, LA 70803, USA, Science, Technology and Toxicology (ST&T) Consultants, 655 Montgomery Street, Suite 800, San Francisco, CA 94111, USA, Division of Biotechnology and Molecular Medicine (BIOMMED), LSU School of Veterinary Medicine, Skip Bertman Drive, Baton Rouge, LA 70803, USA, Lily of the Desert, 1887 Geesling Road, Denton, TX 76208, USA, http://articles.timesofindia.indiatimes.com/2012/jun/26, http://www.iasc.org/pdfs/11_0427_Position_Statement_NTP_CONSUMERS.pdf, http://www.webmd.com/vitamins-supplements/ingredientmono-607-ALOE.aspx?activeIngredientId=607&activeIngredientName=ALOE, http://www.cancer.org/treatment/treatmentsandsideeffects/complementaryandalternativemedicine/herbsvitaminsandminerals/aloe, http://www.newscientist.com/article/dn20365-aloe-vera-extract-gave-rats-tumours.html, http://www.nlm.nih.gov/medlineplus/druginfo/natural/607.html, http://www.iasc.org/InsideAloe/10_0218_IAO.pdf. Lily of the Desert has been a leading producer of Aloe vera products since 1971. Aloe Vera extracts or juices are processed from the pure inner gel to concentrate the beneficial compounds and create a drinkable liquid that mixes easily into other beverages. One control female rat developed a facial swelling during the study. Formulation on Letrozole induced polycystic ovarian syndrome rat model,”, B. O. Lim, N. S. Seong, R. W. Choue et al., “Efficacy of dietary Aloe vera supplementation on hepatic cholesterol and oxidative status in aged rats,”, S. Rajasekaran, K. Ravi, K. Sivagnanam, and S. Subramanian, “Beneficial effects of Aloe vera leaf gel extract on lipid profile status in rats with streptozotocin diabetes,”, D. Brusick and U. Mengs, “Assessment of the genotoxic risk from laxative senna products,”, T. T. Kararli, “Comparison of the gastrointestinal anatomy, physiology, and biochemistry of humans and commonly used laboratory animals,”, R. F. Wang, W. W. Cao, and C. E. Cerniglia, “PCR detection and quantitation of predominant anaerobic bacteria in human and animal fecal samples,”, M. Hattori, T. Kanda, Y. All mice were purchased from Jackson Laboratories, Inc. and were ordered between 4 and 6 weeks of age. In addition, mice were monitored for a weight loss of 10% or greater, decreased feed consumption of 10% or greater, and death. Examinations included large intestinal histology to understand if aloe beverages derived from DCWL aloe vera juice produced toxicologic signs associated with nondecolorized whole leaf juice. This mucosal and goblet cell hyperplasia was also observed in rats at 13 weeks. Although consumer interest in aloe likely stems from its association with several health benefits, a concern has also been raised by a National Toxicology Program Report that a nondecolorized whole leaf aloe vera extract taken internally by rats was associated with intestinal mucosal hyperplasia and ultimately malignancy. The blank plate without S9 showed a similar number of revertant wells in aloe plates of 21x, 14x, or 7x (Table 1(a)). % nonaqueous. Lily of the Desert Aloe Vera Juice, No Preservatives, Inner Fillet, 128 Ounces. 4 . Care for your body inside and out with Lily of the Desert aloe juice. Face Masks & Hand Sanitizers. Liquid Aloe Vera Juice 16 oz. Abdominal, pelvic, and thoracic organs were observed in situ, then the liver, kidneys, testes (in males), heart, and lungs were removed, weighed, rinsed with phosphate-buffered saline (PBS), and placed into 10% neutral buffered formalin (NBF). The juice product also did not show significant concentration-related DNA damage/repair in the presence of metabolically active liver extract (Figure 1(b)). International Aloe Science Council, Position Paper of the International Aloe Scientific Council on The National Toxicology Program Study of Orally-Ingested Aloe Vera, 2011, National Toxicology Program Report, “Toxicology and Carcinogenesis Studies of a Nondecolorized Whole Leaf Extract of Aloe Barbadensis Miller (aloe vera) in F344/N Rats and B6C3F1 Mice (drinking water study),”, M. K. Park, “Analysis of 13 phenolic compounds in Aloe species by high performance liquid chromatography,”, L. E. Sendelbach, “A review of the toxicity and carcinogenicity of anthraquinone derivatives,”, D. K. Patel, K. Patel, and V. Tahilyani, “Barbaloin: a concise report of its pharmacological and analytical aspects,”, National Toxicology Program, “NTP toxicology and carcinogenesis studies of EMODIN (CAS NO. As a positive control for direct acting mutagenesis (i.e., independent of metabolic conversion), either sodium azide (0.38 μM final concentration) or 2-nitrofluorene (7.1 μM final concentration) was included in one plate. Lily of the Desert Aloe Vera Juice. ALOE DIVISION WEBSITE. Most aloe anthraquinones exist as glycosides, which are rarely mutagenic [33]. We are committed to sharing findings related to COVID-19 as quickly as possible. Cage changes with fresh litter and fresh water were provided weekly to the mice. Feed consumption and body weight changes during the 13-week period were compared using two-way repeated measures ANOVA with Bonferroni post-tests. One female rat died during transport from the vendor, and thus the control group of females contained 6 rats, while all other groups contained 7. The authors gratefully acknowledge the Division of Laboratory Animal Medicine staff and attending veterinarians at the LSU-SVM. 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